Within the course of a preclinical study covering in vitro and in vivo analyses, the effect of a polyphenol-rich maqui berry extract (Delphinol®) on bone metabolism with focus on bone density and mineralization was investigated with special regard to the influence of the anti-oxidative potency of the compound. The extract not only inhibited osteoclastogenesis and thus protected against bone loss in two osteopenic mouse models but also stimulated formation of new bone and enhanced mineralization.
